Re: iMac updated using OpenCore causing Sims 4 issues
If you've hacked your Mac to install an OS that isn't supported normal game troubleshooting can be tricky. Whilst you may have a somewhat stable Sequoia build, you're running it on hardware that isn't supported which can affect all other Apps. If your Mac has a Radeon R9 290 is it a 2015 iMac? If so, is there a specific reason you're trying to get it to run an unsupported version of macOS? Or were you just tinkering around (totally understand if so, it's fun, but can have consequences). TS4 runs fine on Big Sur, the last supported OS on that model Mac.
Your GPU is listed as compatible in the GraphicsCards.sgr file:
card 0x67B0 "AMD Radeon HD R290 X2" $cardLevelUber $resolutionHigh
but maybe the DeviceID is different in which case you need to add it - https://bluebellflora.com/sims-4-how-to-add-your-gpu-to-the-graphicscards-sgr-file/