I haven't had the issue in a couple weeks but back when I was having this problem,I could get it to fix itself by doing "Ctrl+Alt+Delete". I wouldn't have to close anything and really take any further action, but calling it up and toggling out of the game and back in seemed to kick-start it again and it would resume. I would then be able to re-save it successfully.
So this isn't a real fix but I would suggest trying it since it's quick and easy.
I would also suggest clearing the cache and that type of stuff
- Delete the localthumbscache.package file in this directory. ...
- Go inside the cache folder and delete all files that end in .cache, but do not delete the actual directory.
- Go back, then to the cachestr folder.
Also, if it's been ages since you played you might want to do a clean install.