What Crinrict is saying is basically try a Sims 4 factory reset -
Move the Sims 4 folder from the Electronic Arts folder to the desktop, for testing purposes and to backup your Sims 4 files.
Repair the Sims 4 game. In Origin - right-click on Sims 4 and select Repair.
After repairing the game, try a new game save without mods. to see if you continue to have issues with your game.
If all goes well with a new game. You can copy your old saved games from the Sims 4 folder on your desktop to the new Sims 4 folder in [C:\Users\Username\Documents\Electronic Arts\The Sims 4].
Try playing one of the older saved games. If that goes okay, start to put back the other files and folders. (list of files and folders below).
- Options.ini (or just re-set all your settings manually)
- Tray Folder
- Screenshots/Videos/Custom music
- Rest of the save games, if any. (leave out slot_00000001.save which is the autosave which is not used anymore.)
- Custom content like clothing, hair, skins, make up ....
- Mods (one by one, making sure they all still work)
Please note some mods and custom content become outdated with every game patch released. This means you'll need to go through your mods folder to find what needs to be replaced.
Finding Problem CC
http://modthesims.info/wiki.php?title=Game_Help:Finding_Problem_Custom_Content
Hopefully this helps and all goes well.