Yes I do use CC, but that has never made my game unable to even play in the first place. I HAVE had custom content files that corrupted my game, but all that did was that it would stop responding while the game itself was loading.
This is what happens when I try to start my Sims 4; so I log into Origin and press 'Play' on TS4. The Play button then becomes greyed out for a couple seconds, and then it goes back to being orange as if I had never clicked it and started the game in the first place. If I look on the Task Manager, it shows that The Sims 4 is running for a couple of seconds, then it disappears.
Also I've linked the DxDiag file too if you wanted to see that 🙂