Re: "There is a problem with your game's setup. Please reinstall your game." - Sims4

@MacAttackPotato  Please run a dxdiag and attach it to a post.

https://help.ea.com/en-us/help/pc/how-to-gather-dxdiag-information/

Please also list the antivirus you use and where Sims 4 is installed.  For the latter, open the EA App game library, click Sims 4, and select Manage > View properties.