Re: TS4 wont load - other games fine?

@KoalaKevxo  Personally, I'd be hesitant to ask someone from IT to change the security settings on a work computer, especially if it's just so I can run a game.  But I don't know what the official policy on the matter is in your office; maybe it would be seen as a reasonable request.

Anyway, Sophos is known to conflict with Sims 4, and the symptoms you've described are exactly what happens when an antivirus prevents the game from running, so I'm not sure there's another way to get it working.