Only the resource.cfg in the games mod folder matter. That you have one somewhere else doesn't matter.
Move your Mods folder to the Desktop and delete localthumbcache.package. Then test the game in a new save.
If it works now check for updates to your Mods and CC. Add it back a little at a time while testing until you have found all that are broken.
What happens if you have two resource.cfg in your mod’s folder?
@haileybug26 Probably nothing. Since two files can't have exactly the same name in the same location, one copy will have been renamed, and the game likely ignores this file completely. Still, I'd delete both and let the game create a new one.
Since this thread is a bit old, I'll lock it here. If you need more help, please post in the Mods/CC Issues forum:
https://answers.ea.com/t5/Mods-CC-Issues/bd-p/the-sims-4-game-issues-mods-en
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