@Fleuwz Please make sure you've covered all the Avast settings listed here:
https://crinrict.com/blog/2020/10/add-exceptions-to-anti-virus-programs.html
Try disabling your Adobe software as well. I don't know why it would interfere, but one other player did report that it helped, and a component of the software is crashing repeatedly, according to your dxdiag. So it's worth trying. You can open the Task Manager and close any Adobe processes that appear; be sure to check the background processes list as well.
Please continue to test with a clean Sims 4 folder, as in, your existing folder needs to either be renamed (as you've done already) or be moved to a different location.
If these steps don't help, please look for related entries in the Reliability Monitor. Hit Windows key-R and enter "perfmon /rel" without quotes. You'll see a list of errors and updates, with a column for each day. (Today is all the way on the right.)
For any errors that mention Origin or Sims 4 starting now, click "View technical details" and copy the info. You can post the text in a reply, or paste it into a text document and attach the file. Sometimes the Reliability Monitor doesn't update right away, so if you don't see any related errors, be sure to check back an hour or two. The timestamp on the initial chart can also be off by up to an hour, so that's not an entirely reliable metric, but the one within the technical details should be accurate.
