Okay I've tried everything listed in this thread and I keep running into the same problem: I go to create a new sim and either it would crash as soon as I selected her hair color or clothing, or prior to trying the above mentioned, I got as far as being able to play, but then the game would crash on one random screen or another, and finally the sim I created somehow got corrupted and everytime I would click on her lot the game would crash. So I uninstalled the whole thing, reinstalled using the tips listed above, and now this is where I am currently re: crashing when I try to create a sim.
I'm guessing I won't be able to create a sim without the game crashing on me, I'm very disappointed as I have this game and all the expansion packs and can't play it on my old laptop... too slow, and my previous vista desktop crashed and burned years ago. So now I guess I'm just SOL. I'm going to try running as administrator and windows 7 compatibility and see if that works. And I'm going to try NOT creating a new sim and see what happens if I try playing with one of the game characters.
I installed using the C:\Program Files\EA GAMES\The Sims 2 path and also followed the manual install tips.