My town is organized into themed "blocks." I have a poor neighborhood, a regular neighborhood, an apartment block, and a mansion district. I have a block that's basically a strip mall, and I have a slightly more "upscale" shopping area. I have a cheap restaurant block and a nice restaurant block. I have an entertainment district with the arcade, wax museum, bowling alley, etc. I also have a red-light district with the strip clubs, bars, casino and race track. I also have a Christmas area, an industrial park, and a big forest off on one edge.
There are a few blocks that were just sort of tossed together for the moment. I'll probably work on them more when I get a chance. I'm probably going to do some major reorganization after I get the last strip of land.