Yes it does crash with more than 99. Usually that's because Cheat Engine was on and Unlimited potions and Free crafting was checked. Rarely it's because you didn't turn items in and have collected too many. If that is the case, reload to a save before you had too many or, simply don't turn in research items for the rest of that game and, remember to do so more often in future games. They cannot be sold nor destroyed so, those are the only options. I know that means you have them clogging your inventory but, it's all we can do without using a third party inventory editor which I've never needed to do but, others here my be able to recommend one for you.
