My mouse has disappeared.

I do not run the game with any mods, I do not and will not use any controllers on my PC.
The game played perfectly as of last night, mouse and all. 
This is an entirely new issue for me as of this morning. 
The fixes I was able to find haven't solved this issue. 

All drivers are updated, the mouse is relatively new as well. 
I cannot click anything in the menu, nothing. 
The mouse functions perfectly with every other game and application. 

Other than not playing, is there any easy solution for this? 

Going into the program files didn't work, nothing has. Thanks all.