Can't interact with chests containing unique items [PC]

I'm having the issue, have not been able to open those chests for most of the game, just in the beginning.  Very frustrating.  Actually having issues with many of the prompts, some that have essentially blocked me from finishing quests. 6-month-old gaming pc which is a beast. Game breaking issues should be sorted before release and from what I've seen online this is a very common problem.