Unable to interact with Unique chests, Skill Point statues and Health Up statues

Update on my same situation.  I recently finished the game with about the last 25% bugged and could not open any of the big chests or interact with the statues, etc... so I really missed out on a LOT  of items.  I started a new game yesterday and kept saving about every 10 min just in case.  The same "no dagger" bug hit me around act 3 I think.  Immediately I tried loading my  previous save, (which was a "good" save with the dagger working at the time that I made it), but somehow it also had become bugged and the dagger did not work any longer on that save.  So, I kept trying every save in reverse order working my way backward in the load a save list but they all had changed from "good" saves to "bad/bugged" saves.  I had to go back about 10+ saves before I got to where the dagger showed up again.  Fortunately I only lost about 1 hr+ of playing.  Now I'm saving about every 5 minutes just to try and be really thorough!  :)