Mass Effect 1 don´t open

@Sovereygn 

• Go here and download the "CCleaner". (The freeware version.)
• Uninstall the game via the Windows control panel if you can find it. (If not just continue.)
• Run the "CCleaner" > Registry (left bar.) > Scan for errors.
• Fix selected errors > Run the backup > Clean up entries.

Than:

Clear your Origin cache.
All settings in Origin (only in Origin not in the games) are back to default settings after this.)

• Close Origin completely.
  (right click on the Origin symbol in the task bar > close)
• Press the Windows key and "R" at the same time.
• Type or copy and paste "%ProgramData%/Origin" (without quotes) into the new window > hit ENTER
• Delete all the files and folders in the Origin folder, except for the "LocalContent" folder.
  (The "LocalContent" folder must remain untouched.)
• Press the Windows key and "R" at the same time.
• Type or copy and paste "%AppData%" (without quotes) into the new window > hit ENTER
• Now your Windows explorer should have brought you to your "C:\Users\>your user name<\AppData\Roaming" folder.
• Delete the "Origin"  folder inside the "Roaming" folder.
• In the address bar of your Windows explorer click on "AppData".
• Open the "Local" folder.
• Delete the "Origin"  folder inside the  "Local" folder.
• Restart your PC.

Now run Origin as Administrator (Right click the Origin desktop shortcut > Run as Administrator.)  and try to download and install the game again.

@Sovereygn Yes. It was resolved with the help of @ Holger1405.
In my case, it was IBM Trusteer Rapport that was preventing the games from opening. The errors you reported were not displayed. After uninstalling IBM Trusteer Rapport everything worked normally.

@holger1405 Once again, thank you very much for your help on another page. Uninstalling IBM Trusteer Rapport, as suggested, solved the problem.