I had the same exact issue and for me it was Origin in-game. Most of the answers I've seen on this and other forums are far too complicated.
Unfortunately EA in all their infinite wisdom have an application override on Origin in-game that can only be disabled by right clicking the game in Origin, clicking game properties and then unchecking the allow Origin in-game checkbox. I had to do this even though Origin in-game was disabled via the settings menu that was previously suggested. After doing that, it worked fine. Didn't have to do anything else.
EA, if you're listening: your Origin product is trash. So is Origin in-game. Origin can't even run at a respectable resolution by default on my pc. When your own launcher breaks your own games, that's a bad sign. Maybe you should fix that? Can you guys maybe allocate some Mass Effect developers to fix your Origin product? Please?
DICE Team
