I have the same problem too.
ME3 crashes here and there especially during multiplayer for about a week or two.
Sometimes ME3 stops working even directly after starting the game from Origin and not even going to the option screen.
I moved to Win8 since January 31st., 2013.
ME3 starts cashing about 2 weeks after moving to Win8.
Either some new patches from Microsoft or new patches from ME3 are the cause.
Those crashes were new for me, I did not have them under Win7.
Please respond to this problem.
System:
Q6600
Shappire HD6850 1GB
P5X38
6GB DDR2 800 CL5 RAM
Win 8 pro x64
Crucial M4 128GB (OS and ME3 are here)
Seagate 7200.14 3TB
Set to:
1680x1050
all maxed
Others (always active even since Win7 on my PC. ME was running ok with them on Win7 pro x64):
PeerBlock
Avast
Spybot
