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No I have ME3 installed on my F: drive. My C: drive only has Windows and the Witcher 3 on it.
And I have already tried the windowed mode fix several times with the exact same results.
The DLL file you replaced, was that the "awc.dll"?
- If not shout down Origin completely.
- Download the awc.dll zip file from here.
- unzip the file.
- Navigate to your ME3 "Core" folder. (should be "F:\Program Files (x86)\Origin Games\Mass Effect 3\Binaries\Win32\Core"
- Make a backup copy of your AWC.dll.
- Move the new "awc.dll" file from the location you unzipped the file into the "Core" folder.
- Start origin and test.
If that still not helps, I would suggest to install ME3 to your C: drive because there were reports that sometimes ME3 can't get lunched from another drive.
I don't know the reason for that error because I myself run ME3 on my D: drive, but it happened.