Mass Effect 3 Wont Launch Windows 10

@W1ldkat

And you tested this game now again?

Please preform a clean boot and test the Game afterwards.

@holger1405

Yes I did.

I ran a clean boot and it still came up with the same error.  However, the process opened for a full 20-30 seconds in task manager (although was only using cpu for a couple seconds) this time prior to closing.   Typically it only stays open for 3-5 seconds.

Edit: added error report

Description
Faulting Application Path: S:\Games\Mass Effect 3\Binaries\Win32\MassEffect3.exe

Problem signature
Problem Event Name: APPCRASH
Application Name: MassEffect3.exe
Application Version: 1.5.5427.124
Application Timestamp: 50d4cab0
Fault Module Name: nvcuda.dll
Fault Module Version: 6.14.13.7849
Fault Module Timestamp: 58820db6
Exception Code: c0000005
Exception Offset: 002ab23b
OS Version: 10.0.14393.2.0.0.256.48
Locale ID: 4105
Additional Information 1: 2beb
Additional Information 2: 2beba6fb4680d73a8c78ca7c24ccdb46
Additional Information 3: 9cd2
Additional Information 4: 9cd2e275ccb4247c4efe4926a99dfc92

Extra information about the problem
Bucket ID: 34e221eba0fe08df399cd8445a37ae01 (108705404769)

@W1ldkat

I would love to say that is a step forward, but that would be exaggerated much...

Is your virus scanner still disabled? If not could you try to completely uninstall it and test again? (Please still in clean boot mode, you can go offline if you don't want to disable the virus scanner online.)

 On second attempt the process closed in 5 seconds again. I think the delay may have been completely unrelated. 

Yes, both windows firewall and AV are off.   I am only using windows defender which as far as a i know is part of windows 10 and cannot be removed. 

@W1ldkat

You're right it cannot, and it probably wouldn't cause such issue.

But this is a strange issue, it makes no sense. 

The only ideas I have left on the software side are creating a new Windows user account (to test for problems inside your current account) or installing the game to your system drive.

@holger1405

Using a different user account did not solve the problem.  I will move the install to my C drive and see if that works.  The only other thing I can think of is reinstalling Windows 10.. which is a stretch but I have my doubts this is an nvidia issue.

Looks like another user had a similar problem even when attempting to run off on-board graphics.  Unfortunately there was no solution posted.

http://answers.ea.com/t5/Technical-Issues/Some-games-wont-launch-in-reinstalled-Origin/td-p/5398595

@W1ldkat

That the is of course very well possible.

Good to hear that it works now. Have fun Gaming.