[PC, Windows 10] - Mass Effect (2007) Freezes on main menu after reinstall

See title. I reinstalled Mass Effect after installing a couple of mods caused the game to fail to launch - immediately prior to installing the mods, the game launched and ran fine. Here are the two mods I tried - ME1 Recalibrated, MERLIN.

I uninstalled using the EA app, deleted the "Mass Effect" folder in the 'This PC\Documents\BioWare' directory and then reinstalled via the EA app. I did not try to reinstall the mods; the freeze occurs with the vanilla install.

The seems to freeze after a very consistent amount of time, less than 10s, after launching and requires the task manager to close. If I let the intro vidoes play, it freezes before "Demiurge Studios" appears and if I spam Esc, it freezes at the transition from the title screen to main menu.

Things I've tired

• Running as admin + XP SP3 compatibility mode
  
• Not running as admin + XP SP3 compatibility mode, RUNASINVOKER via registry editor string
  
• Installing legacy PhysX system software 

  https://www.nvidia.com/en-us/drivers/physx/physx-9-13-0604-legacy-driver/

• Reparing installation via EA app
• Deleting 'Config' and 'Save' folders in 'This PC\Documents\BioWare\Mass Effect' before launching in offline mode
• Disabling EA app overlay
• Installing OpenAL
• Disabling mandatory ASLR in Windows Defender
• Running 'MassEffectConfig.exe' and trying various video and audio settings before launching
  • Eg. Fullscreen vs windowed, vsync vs no vsync, hardware vs sofware audio
• Launching after clean booting

Nothing I've tried seems to affect how the game freezes. I've attached my system's dxdiag info and the latest log file from the Mass Effect Documents folder. I'm at a loss for what to try next. Any and all help is very appreciated!