@limbusy
OK, at this point there are not many options short of reinstalling Windows left.
Create a second Windows user account (Administrator > reboot > logon to the new account and test the game.
If that don't helps, clear your origin cache.
All settings in Origin (only in Origin not in the games) are back to default settings after this.)
- close Origin completely. (right click on the Origin symbol in the task bar > close)
- Press the Windows key and "R" at the same time.
- Type or copy "%ProgramData%/Origin" (without quotes) > hit ENTER
- Delete all the files and folders in the Origin folder, except for the "LocalContent" folder. (The "LocalContent" folder must remain untouched.)
- Press the Windows key and "R" at the same time.
- Type or copy "%AppData%" (without quotes) > hit ENTER
- Now your Windows explorer should have brought you to your "C:\Users\>your user name<\AppData\Roaming" folder
- Delate the "Origin" folder inside the "Roaming" folder
- In the address bar of your Windows explorer click on the word "AppData".
- Open the "Local" folder
- Delate the "Origin" folder inside the "Local" folder
- Restart your PC.
Now deinstall ME3 from the Windows control panel.
Make sure that the "Mass Effect 3" folder under "Documents\Bioware" is also gone.
Use this guide to clear the Registry of your computer with CCleaner. > reboot
Run Origin as Administrator and install the game again. > test.