Mass Effect LE ME2 launcher crash.

Hey,

So MELE played great through ME1, and everything was working just as great through ME2, and I was nearing the last few gameplay hours before finishing.  When I was starting Tali's loyalty mission, I go to save and my system said my C drive was full.  After this alert I tried to delete some saves to make room, but the game froze up and I had to force it closed.

Now I'm a bit confused why it happened this way because I have 2 separate drives, C and K.  K is where my games are downloaded to, and that one has enough space left so that shouldn't be a problem. But I cleared some space in C drive as well and tried to relaunch ME2, but it now crashes during the launcher. 

I have done every possible fix I could crawling through multiple threads and trying everything suggested.  I had to uninstall my AMD and drivers because it wouldn't open (an AMD bug that I was able to get fixed) and reinstall it, and now that works great. I've done the check files thing in steam and in origin, updated drivers, uninstalled and reinstalled the game.  Nothing will get ME2 to launch now.  I've checked both ME1 and 3 in the LE launcher and those 2 still launch fine, but no matter which way I try ME2 will not launch at all.  I am really frustrated because I just want to finish ME2 so I can start ME3 and I am so stinking close! Please help!!!