@ATLAS_3771
As @ThandalNLyman rightfully said, there won't be any more patches for ME1. This Game is almost 10 years old.
Besides that, I have a Logitech G700S and run the newest Logitech software, and the Mouse works flawless in Mass Effect on my system.
Or in other words, there is a incompatibility on your system that is responsible for this error.
Thandal is also right about pointing out that you did necrod an almost 5 years old thread.
If you want help with this issue I would recommend to create a new thread with a DxDiag attached and the steps described that you already tried to solve the problem.
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