Origin (EA) is no longer running. Mass Effect 3 will now close.

Ok, here is  your guy's fix. The problem is that the mass effect game talks to a specific directory and since you didn't install origin to the default location "Program files (x86)/origin", The game was attempting to use a wrong directory to connect to the EA servers. To fix, Install origin without changing the install directory. Allow it to install to C:/Program_files(x86)/Origin