Personally, I have developed a strategy that, while it feels like an ultimate cop out, works surprisingly well.
1) Develop a Remnant assault rifle. One I chose was the P.A.W. It's mostly about Remnant weapons not requiring any ammo.
2) While it's not mandatory, I heavily recommend this step: get a Seeking Plasma Mod and customize your assault rifle with it while you develop it. With that mod, your weapon shoots seeker-type plasma projectiles. They don't do massive damage and are bad against enemies who move, but have one major edge - when your enemy peeks out of cover, they will ruin him without you having to peek out of cover at all - you can blind fire in general direction of the enemy, that's enough.
3) Now, skills. Skill set I'm sticking to is Concussive Shot (Combat skill), Incinerate (Tech) and Energy Drain (Tech). In these skills, invest in upgrades that allow you to hit multiple targets/deal area damage. The later you are in the game, the more your enemies will group up, so ability to hit multiple targets is key. now, here is the way an average fight goes:
- Get to cover
- Fire Incinerate at the nearest target without a shield
- Perform a fire combo by hitting him with Concussive Shot (or Energy Drain, if he's well behind cover; remember that this skill ignores cover as long as you're locked in to your enemy)
- During the rest of your fight, follow this approach: destroy shields of shielded enemies with blind P.A.W. fire from behind cover, then Incinerate them and shoot them with Concussive Shot (CS). If CS is on a cooldown or you're taking damage, use Energy Drain instead to recover part of shields. If enemy is stunned on the ground, blind fire P.A.W. If someone's flanking you, switch to whatever normal weapon you have (for me it's Carnifex pistol) and finish him off the standard way.
- If a single, high-HP enemy shows up, stick to cover, fire Incinerate+Concussive shot, shoot entire charge at the target, rinse and repeat until enemy gets close, evade, do the same thing again. If you get hit, use Energy Drain to get shields back.
So, yeah, while the approach makes gunfights kiiiiind of shallow, it's a very solid choice if you tend to get shot up a lot the normal way and/or you have trouble with conserving ammo. The good thing is, this setup works pretty well against pretty much everything, from Chosen to Architect. While it's not a high DPS loadout, it gives you maximum safety.
Other note: if you're short on resources, you can destroy weapons and armor that you don't need. I would argue that in early stages of the game it's a better idea than selling it.
Ah, and if you're getting into area with hazard level 3, it's the game telling you 'don't go there, you will be able to visit that location later in the game'. Don't be like me, who died a couple of times just because a side quest initially was deep in radioactivity level 3 territory on Eos. The good news is, if your life support is about to run out, you can just teleport to quick travel location by using the map without any negative consequences.