Reapers again?! They´ve been around for "nearly a billion years", it took the Andromeda Initiative -just- 600years to cross from Milky Way to Andromeda without MErelays just using their FTL-drives....I mean, Reapers are pretty useless if they just haunt the Milky Way galaxy knowing there´s the Jardaan in Andromeda and satan knows what else...and then there´s like, like 26 other galaxies in the universe.
I totally expected Andromeda to have atleast some kind of Reaper-monitoring presence, 1/13 or so. of the age of the universe seems enough time to spread alittle further than 1 galaxy, especially if you want to -> “We impose order on the chaos of organic evolution. You exist because we allow it, and you will end because we demand it.”
Suppressing 1 galaxy hardly seems enough to bring down the net entropy of the universe that much.
So, there will be a plot-reveal-event which will state the secret history of ME-universe, that the Reapers are spread thru (a large part of) the (visible) universe and nowhere is safe.
Also a DLC dealing with the Quarian Ark and out pops Tali or something + more Kett with High-Archon or Archon Council or something similar