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Re: Game fails to load, "Failed to initialize the physics system."

This was a problem in ME2 as well. I googled it for you and found the following fix:

Click "Start" --> "Control panel" --> Uninstall a program" locate PhysX in the list, --> "Right click PhysX" --> "Choose Repair"

Source: http://social.bioware.com/forum/1/topic/106/index/843882/1#2567357 (Edit: The forum has been deleted.)

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