Re: Is there any way to play the Mass Effect Trilogy without Origin?
Is that the "api-ms-win-crt-runtime-l1-1-0.dll" error?
Just reinstalling the VC++ 2015 Runtime should solve this problem. You can find it here.
(Install both versions, x86 and x64, run the installer as administrator and reboot after installation.)
BTW, if you try to use the Origin version from a Trilogy disk version it will install an outdated Origin version.
Download Origin from here instead.
As for your question: No, the Trilogy only works with Origin.
You can get ME1 and ME2 on Steam, but ME3 is an Origin original.
