Re: Mass Effect 2 LE minimizing to desktop (PC)
@Lokara Try disabling Origin in-game (and obviously while playing through Origin): hover over your username, select Application Settings, then the Origin in-game header, and disable the option at the top.
If that doesn't help, please try fullscreen, borderless, and windowed modes, and let me know whether the problem is present in all three.
Please also run a dxdiag and attach it to a post.
https://help.ea.com/en-us/help/pc/how-to-gather-dxdiag-information/
And let me know whether you've modded your game or added any graphics enhancement utilities like ReShade.