I created a very low-rent part of town--moved the buildings to a completely service- and specialization-free spot whenever I wanted to upgrade, and kept the neighborhood itself covered only by fire, police, and health.
Then I had another neighborhood that has the more "mid-century" homes, and a few estates. Covered by services, lots of specializations.
I'm getting bugged incessantly to upgrade the low-rent homes, but the nicer ones well-covered aren't offering upgrades at all.
I most definitely want the option to turn off upgrade prompts. I'm totally willing to have to pay simoleons or keys in order to upgrade a building after having turned it off, though.