So much bad information in this thread. I play SimCity 4 on my PC Windows 10. There are some things you need to do to make it compatible. I won't list them here. Google is your friend.
BUT if you got the game through Origin, then you are screwed. Origin does not update the game. The Origin client will tell you that the game is up to date, but the SimCity4.exe file remains at version 1.1.610. To run custom content or mods, you need it updated to 1.1.638 or the latest update, 1.1.641. Origin refuses to do that for some reason. And there are forum posts here on Answers HQ addressing this issue that went ignored for over a year.
On the Maxis Files for SimCity 4 website:
"EP1 Update
The main patch for SimCity 4 Rush Hour / Deluxe.
This update is required as a minimum for most custom content including the NAM. Upon installation, your game will be updated to Version 1.1.638.0 from where the Nightlights Update can then be applied.
Note: Digital versions of SC4 do not require this, providing they are fully patched (1.1.641.0). A notable exception is the Origin edition which is both unpatched and unpatchable, and therefore not recommended."
https://community.simtropolis.com/sc4-maxis-files/