Re: Windows 10?

Hi @DDZ777 - Yes, SimCity via Origin works on Windows 10. I upgraded from Vista (!) to Win 10 (had to move to a new computer, of course). I would make a backup copy of your SimCity Documents folder - default location is C:\<YourWinUserName>\Documents\SimCity copy it to an external drive just in case. If you're upgrading the same computer, you might want to uninstall Origin and your games until the upgrade is done, and then reinstall. If you're moving computers and play Single User / Offline, you can move your games by copying your  \Documents\SimCity\Games folder from the old computer to the new one after installing the game.

A few things to keep in mind that will help:

Always run installation files "As Administrator"
Firewall and Antivirus - Make sure SimCity.exe and Origin.exe are added to exception lists. If you have BitDefender installed, disable it.
Graphics drivers and OS are patched and updated to newest versions
SimCity.exe and Origin.exe - Set them to run "as administrator"
Nahimic 2 & 3 from MSI - this is an audio management program that comes with MSI motherboards. Disable or uninstall it. Nahimic is known to cause issues

If you run into any problems, try these tips:
Disable Origin in-game In Origin main menu, right-click SimCity icon, Game Properties, check the box that says "Disable Origin In-game"
Run in Windows 7 or 8 compatibility mode - right-click SimCity shortcut; choose Properties > Compatibility tab > Check the box to run in Win 7 or 8 compatibility mode

Happy Building!