I'll add a "me too". Sim City stops working and crash to desktop message.
Modern, custom built PC. All other titles work fine.
I will add this interesting note:
SimCity rarely crashed to desktop (though I had other issues, with a city stuck in "processing", etc) until today, when I added in a new Creative Labs PCI_E SoundBlaster ZXr card. Now, I get the "stops working / crash to desktop" message in under 5 minutes of playing a city that previously worked fine.
Note to EA/Origin: FIX THE ISSUE WITH THE new Creative Sound Blaster Cards!