I have a fairly unorthodox droid team, all max Omega'd: HK, GG, 100, B2, JE. B2 is the baby of the bunch as he's the only 6* (dang those Audorium packs!).
For a long time I always prioritised Rey over Ani and would struggle to beat them. Then thanks to a friendly word from some folks on here, I set my sights on Ani off the bat... and it worked. My nightmare team is JKA (L), Rey and QGJ as DPS, RG and STH for tanks. Most droids have an 80 series in there for DPS but I only have GG. They would beat the crap out of me easily as I went for Rey. But when I switched fire to JKA, the whole thing looked very different. Slow and grindy but ultimately a lot more successful. I haven't lost to Ani since.
https://youtu.be/D51um5poR-U
I can see that speed is a great benefit as JE and HK ensure a high speed droid team. But every time you kill his buddy, you give him the ability to nuke you. He's the opposite to OB leads who's always the last to die.