"ZAP;c-2074713" wrote:
Does any of that change and possibly make another set better with each relic level, specifically based on his mastery?
As I understand it, no.
The 'damage' (which is really increase in offense) and defense penetration from relic mastery would impact the actual damage output, but shouldn't change the relative difference.
The only things that should impact the trade-off is offense secondaries (both % and flat) and incomplete gear levels. The impact is not that much though, even with god tier secondaries.