There are videos of R7 nest soloing full R7 Padmé teams. It’s my understanding that a properly modded Nest can solo equivalent Padmé teams at relic levels.
Stack up on Tenacity and Health with Crit Damage triangle. As stated, after enough counters she’ll start OHKO toons. Put the battle on 4x auto (Basics) from the start to get as many counters in as possible.
Add Farmboy lead for extra tenacity if you need it, followed by HY for increased tenacity, offense, and defense with GMT if you’re timing out or dying.