I run NS and always target AOE toons first. That said, I’m typically not concerned with the wedge teams I see unless chaze is included. Add lando to that mix and I will probably avoid it. Without a good taunter tho, I’m not concerned about taking on wedge teams.
I don’t see a lot of NS teams, at least in my shard, so I wouldn’t build a team trying to counter that as opportunities to fight them are few and far between.
Edit: you are right though that the leader ability works well against plague. Wedge himself goes down pretty easy though as I typically one shot him or another aoe toon with talzins special ability.