Yes, you absolutely can run TS3 in Windows 10. I and many others here do so with only minimal issues. The in-game settings will depend on your computer's specs (processor, graphics card, etc.) and if you'd like an expert opinion on which options to use, just list those specs here. The other question would be whether your hardware could handle running Seasons, which is a resource-intensive pack, and not all laptops are built to handle its demands.
If you have a graphics card of sufficient strength, you'd need to cap the frame rates as well. TS3 doesn't have a built-in fps limiter, so the strongest cards can generate frame rates well into the hundreds and even burn themselves out. There are several tools you can use to limit fps, depending on your card's manufacturer.
The other consideration is that the Windows 10 Creator's Update of last summer can interfere with TS3. But you can disable the most problematic features of the update, and you should be able to play without issue.
http://forums.thesims.com/en_US/discussion/comment/15902876/#Comment_15902876
