I've never watched Orphan Black, but isn't the point that they don't know about each other until one of them dies and another sees it? (Spoiler alert; I think it happened in the first episode, so whatever.) You could use CAS to create the sim you want and then place her in half a dozen different houses on the map, give each one a different job and maybe a makeover (or a nraas-enabled personality adjustment), and just see what happens. Would they recognize their similarities? If they were hot-headed or mean-spirited, would they constantly be fighting? You're right, the possibilities are endless and fascinating.