I know you are all tired of hearing about this by now, but sorry. One ongoing game ever, 16 Traveler mod connected worlds. Of course I've had Error12s occasionally, most of us here have, and they were essentially the order of the day back when I played the more crippled Mac version of the game before porting everything over to Windows. Now, hardly ever.
Number of worlds abandoned and moved on from because of Error12s or any other technical reason: 0. Got bored with a couple of them, extracted my sims, and moved on but that's not the same thing as it was my decision to do so.
This would be impossible without NRaas, other tools to keep the game files clean, and just kind of knowing when things feel right with each world vs. something is going wrong and not going to correct itself. AwesomeMod used to help too, until I found NRaas ways to do (almost) everything it can in this regard and sent it packing. And I know I'm not the only one with such a long-running game, I'm just more vocal about it than most.
Players have asked what kind of monster gaming system I must have. I don't invite diehard gamers over to admire my system because they would just point and laugh, then I would have to politely ask them to leave. It's suitable for the game and hits all recommended requirements but, like me, is aging now and gets a bit cranky when started up at times. Nothing special.
When the game starts fighting back on me, either something is wrong and needs to be investigated or I really have gotten sloppy and tried to do far too much within a single game session.