The two heaviest hitting EPs by far are Pets and Seasons. The next two would be Island Paradise and Into the Future (which you do not have). Interesting that you mention Alpine County. That world is beautiful but like some other well-known custom worlds it is so huge that players struggle with it on all kinds of systems if not right away, then after a while.
Nvidia only makes dedicated graphics cards. AMD makes both dedicated and integrated. Both/Either brands are fine for the entire game (all EPs), provided we are talking about dedicated cards of sufficient strength. We can't really go by the brand names, they both make weaker dedicated cards too.
You may need to take out "too many" things, even NRaas StoryProgression as an example, to get to a place where the game runs well. Then very slowly maybe add some back in and test again throughout until you can find a balance between EPs, content, and mods that is reasonably fun to play without overloading things.
