Maybe there's a chance the game might like multi-GPU configurations, at least Crossfire, without some work?
Failing that, it might be running them wild. This game has no v-sync option, so by default, the GPUs run it as fast as they can. This has been known to cause GPUs to overheat, or sometimes fail.
With nVidia hardware/drivers, forcing v-sync in the control panel works. Last I heard, it doesn't with ATI/AMD GPUs, but there's frame limiting software programs out there. I'd look into them and watch temperatures.
