Re: Sims 3 64 bit - Mouse Clicks not recognized
@acfan-69-csup Try disabling the Origin in-game overlay. The option is under Application Settings > Origin in-game.
If that doesn't help, restart your computer and make sure absolutely nothing is running except for Origin and Sims 3. That includes any accessibility-related utilities you might have installed, and make sure they're not automatically running in the background. Please test in both fullscreen and windowed modes and let me know how it goes.