While I understand where you're coming from I think it would be really difficult to truly give Sims the full spectrum of autism. And what about other mental challenges like MPD or BPD? Depression? Sociopathy? And while I wouldn't mind seeing Sims in wheelchairs the last thing I want to see is an incontinent Sim. The Sims, while a "slice of life" game, isn't meant to cover everything in real life. It's a charming and whimsical (and rather whacky) escape from real life and its struggles. I think the things you ask for are better addressed by mods and should not be imposed by default on everyone's game.