Disappearing science career

Product: The Sims 4
Platform:Mac
Which language are you playing the game in? English
How often does the bug occur? Every time (100%)
What is your current game version number? 1.52.100.1220
What expansions, game packs, and stuff packs do you have installed? Expansions: (all packs up to and including Island Living) Get Famous, Seasons, Cats and Dogs, City Living, Get Together, Island Living, and Get To Work. Stuff Packs: My first pet stuff, Landry Day, Fitness Stuff, Bowling Night, Backyard Stuff, Movie Hangout, Spooky Stuff, Romantic Garden, Outdoor Retreat, Spa Day, Perfect Patio, Holiday Celebration.
Steps: How can we find the bug ourselves? Unknown.
What happens when the bug occurs? The bug seems permanent now, no clue what its trigger was as the game was fine the previous day and no modifications or CC was added, nor was there an update. My main Sim family based on myself, my gf, and our dog has a huge mansion, are big celebs, have done several jobs, been turned into mermaids, maxed many skill...point is I've put +500hrs of work into them, but now suddenly they will NOT load. When I go to load them, and only them because I can still load most if not all other households, from the map, I get an error message (included in images) that says they failed to load and I need to restart the game. [In testing I loaded a new game with no CC and the only returning element being a random Sim I made to be an NPC who I reinstalled to be my test family, so I went to give them their old job when I discovered the Science Career path specifically has completely vanished from my game. It's nowhere to be found however the other Get To Work careers do still exist (included in images).] - This section is no longer valid as explained below after further testing. Lastly, upon repeated repairing of the game on Origin a strange error message pops up stating that it needs to download a file and needs permission from my mac, and to hit yes when a prompt pops up, however no prompt ever pops up and the game continues to install whether I close the error message or not (yes, I have also included an image of this message as well, whether it's related or not).
What do you expect to see? My sims to load and continue playing as I have been all month. In other words, the game to work as intended.
Have you installed any customization with the game, e.g. Custom Content or Mods? Not now. I've removed them.
Did this issue appear after a specific patch or change you made to your system? Neutral/Not Sure 

‌

I can no longer load my main Sim family because, I now assume, one sim is currently at the Science Lab. It lets me pick them on the world map (tho it does NOT ask which sim i want to start as like it usually does), goes to a typical loading screen, then right as the music kicks on signifying that it is fully loaded and the plumbob spins rapidly...it suddenly backs out and gives me an Error Message 110: and a bunch of random numbers (included in photos), and then tells me to reload the game. I can then go and pick ANY other family and load my game fine, but my main family is the only one affected that I've found. Edit: I should also point out that I can still fully access them from Manage worlds. From the map screen I can select manage household and adjust them, I just can't play as them.

However, I then completely wiped all mods and save files (backed them up) and repaired the game a number of times. Deleted Options.ini and cache, and most recommended steps. I was able to start a new game and start playing with one of my other characters from my gallery which I have never played but reloaded into the game that I designed solely to be an undercover Alien NPC at the lab. I played her for a few seconds to make sure she got the job at the lab for when I return there with my characters, only to discover...the Science Career is completely gone.

It's not even an option. Actor, Doctor, and Detective are there, but Science is just missing (hence how I connected the dots that my character was at the lab during the last save and thus may be the problem). Again, I have now repaired the game more times than I can track, but have also completely uninstalled the game and reinstalled. I removed all CC and mods, but replaced my save files for a test and still can't load my characters (which are backed up in my gallery in case I need to restart).

Lastly another potentially unrelated, but also could be the problem, issue seems to coincide with all this as about 50% of the time I repair the game through origin, I get a strange error message that says Origin needs to download some files but needs permission and to say yes when a prompt appears. Well, not only does this prompt never appear, but the download continues on even with a big message saying the download has been paused, and my only option is to hit "cancel" on the prompt that says it's pausing the download. I did happen to notice this prompt appear while it was repairing Get To Work specifically, but it also pops up all over the place with other packs as well and I have not noticed anything strange from any other packs.

At this point I can't restart a new game as the Science Career is still completely missing, but I can't play my old files because I can't load them.

I do have a lot of CC but in the form of mostly outfits. I do also have the Cmar nude mod and remove blur mod but that's the only non-clothing mod. Regardless I have removed all mods until I solve the issue but they do not seem to make a difference as the game fully blank vanilla after a reinstall still doesn't work.

HUGE UPDATE EDIT: Rather than rewrite this whole thing because I'm really not sure what happened, but I just logged back on intentionally trying to recreate the errors, and I still couldn't load my family. HOWEVER, I went to another sim's house and checked and they actually could apply to the Science Career. That's when the little lightbulb lit up above my head (in real life) and I realized the character I originally tested...already worked for the Science career hence why it may have been missing. But one more however...I had JUST added her to a brand new game and would not have figured she would have kept her job from being downloaded from the Gallery. So I'm leaving all this up to recap the...adventures...I've gone through to try and solve this weird bug, but at this point it is no longer about the Science Career, but simply for some odd reason I just can't play as my Sims. I am also going to go ahead and start over on testing and start a new game knowing that the science career is at least currently working and may have been a dumb on my part...however, the other two problems still persist. I cannot play as my family in my old save (which I will keep backed up) and for some reason the game still prompts the error when repairing the game, however I now see those as two separate problems and not related in any way to the Science Career.