Game crashing problem

Hello,

One of my saves keeps crashing after playing for only about 5 to 10 minutes. I don't use any mods or CC. I went to the troubleshooting page and tried the suggested fixes. I deleted the localthumbcache, I made sure no background programs are running, I opened a new save, and that save works properly. I even uninstalled the game and did a fresh re-install. But the save I'm writing about still crashes. 

Is there anything else I can try, or have I just lost that game?