Mods are safe - until they aren't. It's something you have to be aware of for this game. The update cycle is so quick that you have to pay attention and make sure to update your mods every single time there is an update for the game. Because a mod that is not updated can break your save and running your save without mods active also has the potential to break your save. To me, it's not worth the trouble of going through all that. 1 or 2 mods is ok, but when you have to update 10+ every month, it becomes a daunting task.
CC objects and clothes are ok to have and don't need constant updating. They do break every now and then, too, though.