I used to play with autonomy on. I was constantly frustrated by them wanting to do things other than what I had planned for them. And mods need to be updated so frequently that I try to have as few as possible (and only from specific mod makers of those that I do have.) Then I tried it with autonomy turned off. I'm *much* happier now. Even with autonomy off they sometimes still do things on their own though. (I have to make sure I have something for them to do if I've had them do a few romantic things or they'll run off on their own to woo hoo!)