I'd happily check and uncheck fifty or more checkboxes per save to customize my experience. I mean, in a way I'm doing this already through MCCC and other mods. But what are the chances for this, if they do not even give us on/off toggles per occult?
At best we'd get something like "Easy", "Normal" and "Hard", and then "Hard" would include everything that makes the game harder, like faster depleting needs AND harder access to distinguished degrees AND higher bills with no option to mix and match. I also do not expect things that are not in the game yet, like language barriers, to get added. In the end I'd continue playing on Easy and stick to my mods and all the new difficulty levels would be there for nothing.