I have stopped using cc and don't regret it at all. With a few DLC installed there is plenty of choice in CAS and build buy. When it comes to mods, it is a different story. I try to keep them to a minimum but there are a few I can't do without. (around 10 or 15 mods or so) The problem with mods is the frequent updates. I don't want to spend hours looking for mods.
But I think the upcoming patch will break the majority of mods. So I might restart and play vanilla for week or two to try out infants. I plan to go back to my modded game afterwards, but who knows. Maybe I will like the unmodded game. Or just do one mod (mccc) and get rid of the rest.